Date: 28-11-2025

India's renowned health research body, ICMR, is planning to undertake a study to evaluate the efficacy of Metformin and Inositol for the treatment of Polycystic Ovarian Syndrome and fertility issues related to it.

Polycystic ovarian syndrome (PCOS) is a common health problem caused by an imbalance of reproductive hormones. The hormonal imbalance creates problems in the ovaries, which in turn disturbs the reproductive health of the female.

Several reports have proved that women with PCOS have higher chances of complications during pregnancy.

In contemporary practice, the use of Metformin and Inositol for the treatment of PCOS is widespread, whoever there is evidence on the efficacy of these two drugs in terms of improvement in fertility and other related outcomes

The ICMR has recently invited expression of interest (EOI): "To undertake a multi-centric randomized controlled trial for evaluating the efficacy of Metformin vs Inositol to improve fertility and birth outcomes among PCOS women".